The Central Nervous System (CNS) plays a major role in the control and regulation of most bodily functions, including awareness, movements, sensations, thoughts, speech, and memory. For the athlete it means coordination, reflexes and responsiveness. The CNS is at the top of the chain that directs and interfaces with all the other systems of the body. In 1962, it was discovered that neuro-stem cells reside in certain parts of the brain, where there is some form of malfunction or trauma2. It was shown that Fibroblast Growth Factors (FGFs) and other signal molecules feed and nurture these neuro-stem cells to help the repair of these malfunctioning cells and any damaged tissue 3.
Research has also revealed clearly that cell cultures show a dramatic increase in peptide and amino acid uptake in the presence of these signal molecules4. This result gives credence to the understanding that CNS development is influenced by a very precise mechanism, which requires a unique set of signal molecules available from embryonic extracts and other sources of neuropeptides. These proteins direct the internal machinery within brain cells and the connective tissue between brain cells. They also can control the chemical reactions that allow brain cells to develop and communicate with each other.
A compelling argument was made for the use of FGFs, when the Johns Hopkins University School of Medicine chose them as a treatment for degenerative neural diseases from a study they conducted in 2005. They used FGFs as a neurogenesis factor, and found that there was a fivefold increase and proliferation of neural stem cells5. Other studies have confirmed the use of FGFs for the neurogenesis of the Central Nervous System.
Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. Stem cells are characterized by their capability to differentiate into multiple cell types via exogenous stimuli from their environment, specifically FGFs. They undergo asymmetric cell division into two daughter cells, one non-specialized and one specialized. NSCs primarily differentiate into neurons, astrocytes, and oligodendrocytesr1. Oligodendrocytessupport the Myelin Sheath, implicated in Athletic Stress Related CNS breakdown.( Click for Image )
This is why our scientists discovered that StemRenu ™ has such a positive influence on an athlete's ability to stay focused, maintain concentration, coordination, and mental clarity by facilitating repair and function of damaged neurons, astrocytes, and oligodendrocytes. Click for Image
We believe any athlete could use more focus, concentration, coordination, and mental clarity - DON'T YOU? ,
(2) Altman, J. (1962) Science 132:1127-1128
(3) Arlotta, P., et al (2003) Exp. Gerontol, 38:173-182
(4) Zilov, V.G. et al, Byulleten' Eksperimental'noi Biologii I Meditsiny, Vol. 114, No. 11, pp 455-457, Nov. 1992
(5) Jin, Kunlin, et al (Dec 2005) FGF2 Promotes Neurogenesis & Neuroprotection and Prolongs Survival in a Transgenic Mouse Model of Huntington's disease, Vol. 102
(r1) reference http://en.wikipedia.org/wiki/Neural_stem_cell
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